Document Detail


Visual attention and autistic behavior in infants with fragile X syndrome.
MedLine Citation:
PMID:  21720726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aberrant attention is a core feature of fragile X syndrome (FXS), however, little is known regarding the developmental trajectory and underlying physiological processes of attention deficits in FXS. Atypical visual attention is an early emerging and robust indictor of autism in idiopathic (non-FXS) autism. Using a biobehavioral approach with gaze direction and heart activity, we examined visual attention in infants with FXS at 9, 12, and 18 months of age with a cross-sectional comparison to 12-month-old typically developing infants. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS compared to typical controls. Look duration and increased latency to disengage attention were correlated with severity of autistic behavior but not mental age.
Authors:
Jane E Roberts; Deborah D Hatton; Anna C J Long; Vittoria Anello; John Colombo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  42     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-10-05     Revised Date:  2014-01-15    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Attention / physiology*
Autistic Disorder / complications,  psychology*
Child Development / physiology*
Cross-Sectional Studies
Early Diagnosis
Fragile X Syndrome / complications,  psychology*
Humans
Infant
Male
Play and Playthings
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
P30 HD002528/HD/NICHD NIH HHS; P30-HD003110-35S1/HD/NICHD NIH HHS; R01 MH090194/MH/NIMH NIH HHS
Comments/Corrections

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