Document Detail


Visual acuity development of children with infantile nystagmus syndrome.
MedLine Citation:
PMID:  21071734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Infantile nystagmus syndrome (INS) can be idiopathic or associated with ocular or systemic disease. The ocular oscillation of INS directly contributes to loss of visual acuity. In this study, visual acuity development in patients with INS was examined.
METHODS: Children with INS were classified as having idiopathic INS (n = 84) or INS with an associated sensory deficit: INS and albinism (n = 71), bilateral optic nerve hypoplasia (ONH; n = 23), or congenital retinal disorder (n = 36). Visual acuity was assessed with Teller cards and/or optotypes, and the data were analyzed for three age groups (<24 months, 24-48 months, and >48 months).
RESULTS: Patients with idiopathic INS showed mildly reduced visual acuity early in life and gradual maturation with age that paralleled a normative curve. Patients with albinism also showed a mild visual deficit early in life but failed to keep pace with the normative curve, showing a gradual increase in visual acuity deficit. Patients with ONH and congenital retinal disorders exhibited more severe visual acuity deficits during infancy. The ONH group displayed slow improvement of visual acuity with a plateau at 24 months through >48 months, with a small increase in visual acuity deficit. The congenital retinal disorder group had no significant change in visual acuity across age and had a rapid increase in visual acuity deficit.
CONCLUSIONS: The pattern of visual acuity development differs among children with INS, depending on the presence or absence of associated sensory system deficits. Careful characterization of visual system differences in patients with INS is important if visual acuity is an outcome in clinical trials.
Authors:
Valeria L N Fu; Richard A Bilonick; Joost Felius; Richard W Hertle; Eileen E Birch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-14
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-05-20     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1404-11     Citation Subset:  IM    
Affiliation:
Retina Foundation of the Southwest, Dallas, Texas, USA. fuv@upmc.edu
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Cross-Sectional Studies
Humans
Infant
Nystagmus, Congenital / physiopathology*
Syndrome
Vision Disorders / physiopathology*
Vision Tests
Visual Acuity / physiology*
Grant Support
ID/Acronym/Agency:
EY05236/EY/NEI NIH HHS; P30-EY008098/EY/NEI NIH HHS
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