Document Detail

Visible and near-infrared spectral changes in the thumb of patients with chronic fatigue syndrome.
MedLine Citation:
PMID:  19248775     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic fatigue syndrome (CFS) patients show a persistent fatigue condition with muscle pain and impairment of concentration, memory, and sleep. Presently, the physiological basis of CFS remains unclear. In this study, spectroscopic differences in the thumb were compared between 103 CFS patients and 122 healthy controls to examine possible changes of levels of oxygenated or deoxygenated hemoglobin. METHODS: Visible and near-infrared (Vis-NIR) spectroscopy was used to examine possible changes in the region of 600-1100 nm. RESULTS: Vis-NIR spectra showed sharp peaks at 694, 970 and 1060 nm and broad peaks in the regions of 740-760 and 830-850 nm. As these peaks are possibly related to oxyhemoglobin, cytochrome c oxidase and water, levels of these factors were compared between the two groups. Statistical analysis of the absorbance of Vis-NIR spectra showed a significant decrease in water content, a significant increase in oxyhemoglobin content, and a significant increase in the oxidation of heme a+a(3) and copper in cytochrome c oxidase in CFS patients. CONCLUSIONS: These changes imply accelerated blood flow and energy metabolism in the thumbs of CFS patients.
Akikazu Sakudo; Yukiko Hakariya Kato; Seiki Tajima; Hirohiko Kuratsune; Kazuyoshi Ikuta
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Publication Detail:
Type:  Journal Article     Date:  2009-02-25
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  403     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Case-Control Studies
Fatigue Syndrome, Chronic / metabolism*
Hemoglobins / metabolism
Oxygen / metabolism
Spectrophotometry, Infrared
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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