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Visfatin genotype may modify the insulin resistance and lipid profile in type 2 diabetes patients.
MedLine Citation:
PMID:  20010475     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: We investigated the role of the -4689G/T promoter variant of the visfatin gene on serum visfatin concentration and biochemical markers in T2DM patient. METHODS: In a cross-sectional study we recruited 93 patients with type 2 diabetes. Laboratory and anthropometric measurements were included FBG, OGTT, HbA1C, lipid Profile, fasting serum visfatin, fasting serum insulin, weight, height, Body Mass Index (BMI) and waist hip ratio (WHR). Genotyping for visfatin gene was performed by using the PCR-RFLP method. RESULTS: Our findings showed significant differences in levels of low density lipoprotein (LDL) cholesterol, total cholesterol, high density lipoprotein (HDL) cholesterol and fasting serum insulin among various types of visfatin genotype (TT, GG, and GT). This study showed a significant correlation between circulating levels of visfatin and weight, BMI, hs-CRP and fasting insulin in TT genotype. But regarding GG genotype only fasting insulin had a significant correlation with circulating visfatin. CONCLUSIONS: Visfatin genotypes may account for insulin resistance and levels of lipid profile that may cause by different visfatin expression between genotypes.
Authors:
K Mirzaei; A Hossein-Nezhad; M Javad Hosseinzadeh-Attar; N Jafari; A Najmafshar; N Mohammadzadeh; B Larijani
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Minerva endocrinologica     Volume:  -     ISSN:  0391-1977     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran - emrc@sina.tums.ac.ir.
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