Document Detail

Visfatin genotype may modify the insulin resistance and lipid profile in type 2 diabetes patients.
MedLine Citation:
PMID:  20010475     Owner:  NLM     Status:  Publisher    
AIM: We investigated the role of the -4689G/T promoter variant of the visfatin gene on serum visfatin concentration and biochemical markers in T2DM patient. METHODS: In a cross-sectional study we recruited 93 patients with type 2 diabetes. Laboratory and anthropometric measurements were included FBG, OGTT, HbA1C, lipid Profile, fasting serum visfatin, fasting serum insulin, weight, height, Body Mass Index (BMI) and waist hip ratio (WHR). Genotyping for visfatin gene was performed by using the PCR-RFLP method. RESULTS: Our findings showed significant differences in levels of low density lipoprotein (LDL) cholesterol, total cholesterol, high density lipoprotein (HDL) cholesterol and fasting serum insulin among various types of visfatin genotype (TT, GG, and GT). This study showed a significant correlation between circulating levels of visfatin and weight, BMI, hs-CRP and fasting insulin in TT genotype. But regarding GG genotype only fasting insulin had a significant correlation with circulating visfatin. CONCLUSIONS: Visfatin genotypes may account for insulin resistance and levels of lipid profile that may cause by different visfatin expression between genotypes.
K Mirzaei; A Hossein-Nezhad; M Javad Hosseinzadeh-Attar; N Jafari; A Najmafshar; N Mohammadzadeh; B Larijani
Related Documents :
18501125 - Strict control of modifiable cardiovascular risk factors in patients with type 2 diabet...
16857835 - L-rhamnose and lactulose decrease serum triacylglycerols and their rates of synthesis, ...
10067265 - Genetics and metabolism of lipoprotein(a) and their clinical implications (part 1).
14762655 - Effects of a long-term treatment with raloxifene on insulin sensitivity in postmenopaus...
7789635 - Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle.
24701225 - Influence of lifestyle on the course of type 1 diabetes mellitus.
Publication Detail:
Journal Detail:
Title:  Minerva endocrinologica     Volume:  -     ISSN:  0391-1977     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran -
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oral signs in the diagnosis of celiac disease: review of the literature.
Next Document:  Epidemiology of Nosocomial Infection in 125 Italian Intensive Care Units.