Document Detail

Viscosupplementation with hyaluronic acid in hip osteoarthritis (a review).
MedLine Citation:
PMID:  18991239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Viscosupplementation (VS) with hyaluronic acid (HA) is largely used for knee osteoarthritis therapy, but the evidences for its usefulness in hip osteoarthritis (OA) are limited. METHODS: In this review, an extensive search of published trials on VS in hip OA was performed. From the selected papers the following data were extracted: sample size, inclusion/exclusion criteria, treatment procedures, evaluation methods, follow-up duration and clinical outcomes. RESULTS: The level of evidence was low in quite all the trials (no placebo controlled groups). A reduction of pain and an improvement of function after 3 months, persistent in the long term (12-18 months), was observed. Patients with mild morphological alterations responded better to therapy. Side effects were negligible, and were limited to pain and a sensation of heaviness in the injection site. No clear differences among Low (LMW) and High Molecular Weight (HMW) HA preparations were found in the clinical outcomes. However, for HMW-HA preparations, a lower number of injections was, in general, necessary in order to reach the therapeutic effect. CONCLUSIONS: Despite the initial promising results, some questions still remain open : 1) the characteristics of responders must be more precisely defined; 2) the treatment schedules, at present mainly based on the individual clinical experience, need a proper and accepted standardization. Finally, larger and placebo controlled trials are necessary to confirm the efficacy of VS in hip OA.
Michele Abate; Patrizia Pelotti; Daniele De Amicis; Angelo Di Iorio; Stefano Galletti; Vincenzo Salini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Upsala journal of medical sciences     Volume:  113     ISSN:  2000-1967     ISO Abbreviation:  Ups. J. Med. Sci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-02-04     Revised Date:  2009-03-02    
Medline Journal Info:
Nlm Unique ID:  0332203     Medline TA:  Ups J Med Sci     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  261-77     Citation Subset:  IM    
Postgraduate School of Physical Medicine and Rehabilitation, University G. D'Annunzio, Chieti-Pescara, Italy.
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MeSH Terms
Clinical Trials as Topic
Hyaluronic Acid / administration & dosage,  therapeutic use*
Osteoarthritis, Hip / drug therapy*
Osteoarthritis, Knee / drug therapy
Treatment Outcome
Viscosupplementation / methods*
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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