Document Detail

Viscosity, cerebral blood flow and haematocrit in patients with paraproteinaemia.
MedLine Citation:
PMID:  7376819     Owner:  NLM     Status:  MEDLINE    
It has been suggested that blood viscosity is involved in the control of cerebral blood flow (CBF) (Thomas et al. 1977a, b, Humphrey et al. 1979). CBF, using the intravenous Xenon133 technique, blood viscosity and haematocrit were measured in 21 patients with elevated viscosity due to paraproteinaemia and found to be the same as in normal subjects. However, the paraproteinaemic patients were anaemic with a mean haematocrit of 0.342. This degree of anaemia would normally be associated with a high CBF. The paraproteinaemic patients were then compared with a group of 10 anaemic patients with matched haematocrits but without paraprotein bands. The whole blood and plasma viscosities were significantly higher in the paraproteinaemic patients and the CBF was significantly lower. The haematocrit, and therefore oxygen carriage, was similar in the two groups. It is likely that in the anaemia of paraproteinaemia the expected increase in CBF did not occur because of the limiting factor of increased viscosity. This suggests that in this instance viscosity rather than oxygen carriage is a major determinant in the control of CBF. This is further emphasized by the better correlation between CBF and blood viscosity than between CBF and haematocrit. It seems likely that viscosity and oxygen carriage are independent variables in the control of CBF.
P R Humphrey; G H du Boulay; J Marshall; T C Pearson; R W Russell; N G Slater; L Symon; G Wetherley-Mein; E Zilkha
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  61     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  IM    
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MeSH Terms
Anemia / physiopathology
Blood Viscosity*
Cerebrovascular Circulation*
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Middle Aged
Oxygen / blood
Paraproteinemias / blood*,  physiopathology
Paraproteins / analysis
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Paraproteins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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