Document Detail


Viscoelasticity of hyaluronan and nonhyaluronan based vocal fold injectables: implications for mucosal versus muscle use.
MedLine Citation:
PMID:  17334315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to measure and compare biomechanical properties of commonly used vocal fold injectates Cymetra, Radiesse, Restylane, Hylaform, and one investigational injectate, Carbylan-GSX 5%, to determine suitability for mucosal injection.
STUDY DESIGN: Rheologic investigation.
METHODS: Oscillatory shear stress was applied to five samples of each injectate using a parallel plate controlled stress rheometer. Shear stress, shear strain, and strain rate associated with the oscillatory shear deformation were computed from the prescribed torque and measured angular velocity; viscoelastic data were obtained on the basis of these functions. Values calculated included elastic shear moduli, viscous moduli, and dynamic viscosity as a function of oscillatory frequency (0.01-150 Hz).
RESULTS: Elastic moduli for all samples increased as the frequency increased. Hyaluronan based materials were all comparable with each other and at least an order of magnitude lower than the stiffer and more viscous Cymetra and Radiesse. Carbylan-GSX 5% was found to have almost identical values to Hylaform with the exception of its mean viscosity, which was noticeably lower.
CONCLUSIONS: Hyaluronan based biomaterials offer less resistance to flow and stiffness and may be better suited for injections into the mucosa, whereas Cymetra and Radiesse appear to be appropriate for injections into muscle. Viscoelastic properties of Hylaform and Carbylan-GSX 5% were found to most resemble that of the human vocal fold mucosa.
Authors:
Trace Caton; Susan L Thibeault; Sarah Klemuk; Marshall E Smith
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  117     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-04-03     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  516-21     Citation Subset:  IM    
Affiliation:
Division of Otolaryngology-Head and Neck Surgery, The University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / administration & dosage*,  chemistry*
Collagen / administration & dosage,  chemistry*
Drug Administration Routes
Elasticity
Gelatin / administration & dosage,  chemistry*
Humans
Hyaluronic Acid / administration & dosage,  analogs & derivatives*,  chemistry
Injections
Muscle, Smooth
Respiratory Mucosa
Shear Strength
Viscosity
Vocal Cords*
Grant Support
ID/Acronym/Agency:
2R01 DC4336/DC/NIDCD NIH HHS; F31 DC008047-01/DC/NIDCD NIH HHS; F31 DC008047-02/DC/NIDCD NIH HHS; T35 HL07744/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Cymetra; 0/carbylan-GSX; 0/hylan-B gel; 9000-70-8/Gelatin; 9004-61-9/Hyaluronic Acid; 9007-34-5/Collagen
Comments/Corrections
Comment In:
Laryngoscope. 2007 Aug;117(8):1506; author reply 1506-8   [PMID:  17762277 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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