Document Detail

Viscoelastic properties of skin in Mov-13 and Tsk mice.
MedLine Citation:
PMID:  15336923     Owner:  NLM     Status:  MEDLINE    
Viscoelastic properties of skin samples were measured in three types of mice (tight skin, Tsk, control and Mov-13), that are known to differ with regard to content of type I collagen. The experimental design used uniaxial stretching and measured the creep response and the complex compliance. The creep response was measured directly. The complex compliance was determined using a Wiener-Volterra constitutive model for each sample. The models were calculated from data obtained by applying a stress input having a pseudo-Gaussian waveform and measuring the strain response. The storage compliance of Mov-13 and control skin were similar and were greater than Tsk (p<0.001). The loss compliance of each group was significantly different (p<0.001) from each other group; Tsk had the lowest and control had the highest loss compliance. The phase angle of the Mov-13 and Tsk were similar and were less than the controls (p<0.001). The creep response was fit with a linear viscoelastic model. None of the parameters in the creep model differed between groups. The results indicate that gene-targeted and mutant animals have soft tissue mechanical phenotypes that differ in complex ways. Caution should be exercised when using such animals as models to explore the role of specific constituents on tissue properties.
Z Del Prete; S Antoniucci; A H Hoffman; P Grigg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomechanics     Volume:  37     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2005-09-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1491-7     Citation Subset:  IM    
Department of Mechanical Engineering, University of Rome La Sapienza, Rome, Italy.
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MeSH Terms
Collagen Type I / physiology*
Mice, Mutant Strains
Mice, Transgenic
Microscopy, Polarization
Models, Biological
Skin Physiological Phenomena*
Tensile Strength
Grant Support
Reg. No./Substance:
0/Collagen Type I

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