Document Detail


Viscoelastic properties of sickle cells and hemoglobin.
MedLine Citation:
PMID:  7115978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The quantitative relationship between deoxygenation and rheological behavior of SS cell suspensions and concentrated HbS solutions has been studied under steady shear (viscosity eta) and oscillatory shear (complex viscosity with viscous component eta' and elastic component eta"). decrease of O2 saturation below 80-85% causes eta, eta' and eta" to increase progressively in SS cell suspensions and HbS solutions. These rheological parameters do not change in AA cell suspensions and HbA solutions following deoxygenation. The deoxygenation-induced increase in eta" of HbS solutions from the unmeasurable level when oxygenated reflects the gelation of HbS. At high O2 saturations, the rheological behavior of the intracellular fluid has relatively insignificant contribution to that of the SS cell suspension. As O2 saturation decreases, the viscoelastic properties of the SS cell suspension become increasingly dominated by that of the intracellular HbS. at a given degree of deoxygenation, eta, eta' and eta" of HbS solutions decrease with increasing shear rate, indicating that HbS aggregates can be dispersed by shear stress.
Authors:
S Chien; R G King; A A Kaperonis; S Usami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood cells     Volume:  8     ISSN:  0340-4684     ISO Abbreviation:  Blood Cells     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513567     Medline TA:  Blood Cells     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  53-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / blood*
Blood Viscosity*
Elasticity
Erythrocytes, Abnormal / metabolism*
Hemoglobin A
Hemoglobin, Sickle
Hemoglobins*
Humans
Oscillometry
Oxygen / blood
Rheology
Grant Support
ID/Acronym/Agency:
HL-07114/HL/NHLBI NIH HHS; HL-16851/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobin, Sickle; 0/Hemoglobins; 7782-44-7/Oxygen; 9034-51-9/Hemoglobin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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