Document Detail


Viscoelastic properties of the human colon.
MedLine Citation:
PMID:  11447026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objectives were to characterize colonic viscoelastic properties of the human descending colon by assessing pressure-volume (P-V) relationships during barostatic balloon distension. In 16 healthy subjects, a balloon was inflated to 44 mmHg and then deflated to 0 mmHg in 4-mmHg steps at 10, 30, and 60 ml/min, allowing volume fluctuations to stabilize at each pressure increment. Thereafter, these "quasi-static" P-V curves were compared with "dynamic" distensions to 300 ml, at 1 and 10 ml/s, before and after intravenous atropine in another five subjects. During quasi-static curves, balloon volume stabilized at each pressure increment. Quasi-static P-V curves were reproducible within individuals and approximated to a power exponential function and revealed hysteresis, indicative of viscoelasticity. Body mass index influenced quasi-static P-V curves during inflation but not during deflation. The colon was less compliant during dynamic distensions at 10 ml/s than during quasi-static distensions. Atropine increased quasi-static compliance and attenuated differences between quasi-static and rapid distensions. We conclude that colonic viscoelastic properties can be assessed by quasi-static P-V curves. Rapid colonic distension activated neural reflexes, thereby reducing colonic compliance compared with quasi-static distensions.
Authors:
A E Bharucha; R D Hubmayr; I J Ferber; A R Zinsmeister
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  281     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-11     Completed Date:  2001-08-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G459-66     Citation Subset:  IM    
Affiliation:
Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. bharucha.adil@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Atropine / pharmacology
Body Mass Index
Colon / drug effects,  physiology*
Compliance
Elasticity
Female
Humans
Male
Middle Aged
Pressure
Reproducibility of Results
Grant Support
ID/Acronym/Agency:
R01-HD-38666-01/HD/NICHD NIH HHS; RR-00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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