| Visceral & subcutaneous abdominal fat in relation to insulin resistance & metabolic syndrome in non-diabetic south Indians. | |
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MedLine Citation:
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PMID: 20516533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & OBJECTIVES:The objective of the study was to determine whether visceral or subcutaneous component of abdominal fat was associated with insulin resistance and metabolic syndrome in non- diabetic Asian Indians. METHODS: This cross-sectional study had on 120 individuals with normal glucose tolerance (49 males and 71 females). A single slice CT scan at L4- L5 was done for measurement of visceral and subcutaneous abdominal fat. Metabolic syndrome was defined according to the South Asian Modified National Cholesterol Education Program Adult Treatment Panel III criteria (SAM-NCEP) criteria. Insulin Sensitivity Index (ISI-Matsuda) was used to assess insulin sensitivity/resistance. RESULTS: Linear regression analysis revealed that visceral, but not subcutaneous fat was associated with serum triglycerides (R(2);=0.457,beta= 0.34; P=0.006), HDL cholesterol (R(2);=0.430, beta= -0.051; P=0.018) and ISI-Matsuda (R(2);=0.437, beta= -0.05; P=0.039) after adjusting for age, gender and BMI. Visceral fat showed significant association with metabolic syndrome (OR: 1.013, 95% CI: 1.001- 1.025; P=0.041) even after adjusting for age, gender, body mass index and glycated haemoglobin whereas subcutaneous fat did not show such an association. INTERPRETATION & CONCLUSION: These results indicate that in non-diabetic Asian Indians, visceral, but not subcutaneous component of abdominal fat is associated with insulin resistance, cardiovascular risk factors and metabolic syndrome. |
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Authors:
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S Sandeep; K Gokulakrishnan; K Velmurugan; M Deepa; V Mohan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Indian journal of medical research Volume: 131 ISSN: 0971-5916 ISO Abbreviation: Indian J. Med. Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374701 Medline TA: Indian J Med Res Country: India |
Other Details:
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Languages: eng Pagination: 629-35 Citation Subset: IM |
Affiliation:
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Dr Mohans' Diabetes Specialities Centre & Madras Diabetes Research Foundation, WHO Collaborating Centre for Non-communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Sectional Studies Diabetes Mellitus Female Glucose Tolerance Test Humans India Insulin Resistance* Intra-Abdominal Fat* Metabolic Syndrome X* Subcutaneous Fat* Tomography, X-Ray Computed |
| Comments/Corrections | |
Comment In:
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Indian J Med Res. 2010 May;131:603-5
[PMID:
20516529
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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