Document Detail

Visceral protection during moderately hypothermic selective antegrade cerebral perfusion through right brachial artery.
MedLine Citation:
PMID:  19811927     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study investigates distal organ protection during moderately hypothermic right brachial artery selective antegrade cerebral perfusion (MHSACP) in patients undergoing aortic arch repair.
METHODS: Fifty patients undergoing ascending aorta/aortic arch repair using the MHSACP technique (study group) were compared with another 50 patients randomly selected amongst those undergoing moderately hypothermic open heart procedures (control group). The data from successive clinical examinations and blood samplings were then compared to detect any sign of distal organ damage attributable to the MHSACP technique.
RESULTS: The mortality rate did not differ between the two groups (2%). The average cardiopulmonary bypass and aortic cross-clamping durations were 154+/-53 min versus 102+/-25 min and 101+/-41 min versus 70+/-31 min for the study and control groups, respectively. The mean MHSACP period was 32+/-14 min (11-81 min) in the study group. The average discharge time was 6.4+/-1.4 days (5-12 days). Repeated clinical examinations revealed no organ dysfunction and there was no difference between the two groups (with the exception of lactate dehydrogenase) with regard to compared biochemical markers, which might be suggestive of a visceral damaging effect of the MHSACP technique.
CONCLUSIONS: The present data show that with the use of MHSACP, distal organs are relatively well protected during aortic arch repairs.
Ahmet Saritas; Umit Kervan; Kerem M Vural; Seref A Kucuker; Soner Yavas; Levent C Birincioglu
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2009-10-06
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  37     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  669-76     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009. Published by Elsevier B.V.
Cardiovascular Surgery Department, Yuksek Ihtisas Hospital of Turkey, Ankara, Turkey.
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MeSH Terms
Aneurysm, Dissecting / surgery
Aorta, Thoracic / surgery*
Aortic Aneurysm, Thoracic / surgery
Brachial Artery
Brain Ischemia / etiology,  prevention & control
Cardiopulmonary Bypass / methods
Cerebrovascular Circulation
Coronary Artery Bypass
Hypothermia, Induced / adverse effects,  methods*
Middle Aged
Perfusion / methods
Postoperative Complications
Viscera / blood supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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