Document Detail

Visceral losses of desflurane, isoflurane, and halothane in swine.
MedLine Citation:
PMID:  1854035     Owner:  NLM     Status:  MEDLINE    
Percutaneous loss of inhaled anesthetics is small relative to their uptake. The minor nature of this loss results in part from the substantial barrier to diffusion posed by the skin. Pleural and peritoneal surfaces pose less effective barriers because diffusion distances are smaller than in the skin. Accordingly, we measured visceral loss to air of desflurane, isoflurane, and halothane from pleural and peritoneal surfaces in five juvenile swine. Pleural and peritoneal losses per percent end-tidal anesthetic correlated directly with the solubility of the anesthetic in blood or tissues. The total pleural losses for the first 30 min of anesthetic administration were desflurane, 1.22 +/- 0.22 mL (mean +/- standard deviation for the 30-min period); isoflurane, 2.34 +/- 0.52 mL; and halothane, 4.69 +/- 0.98 mL; respective peritoneal losses were 0.64 +/- 0.12 mL, 1.23 +/- 0.25 mL, and 2.69 +/- 0.57 mL. Pleural loss per unit time did not change with increasing duration of anesthesia, whereas peritoneal loss increased for all anesthetics. These visceral losses are greater than total percutaneous losses in humans given these anesthetics for the same period of time, but the loss of anesthetic by either route is too small to affect measurements of anesthetic kinetics or recovery.
M J Laster; S Taheri; E I Eger; J Liu; I J Rampil; R Dwyer
Related Documents :
24169445 - Individual and intervention-related factors associated with adherence to home exercise...
8010455 - The effects of halothane and isoflurane on cerebrocortical microcirculation and autoreg...
11049925 - The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.
12419715 - Duration of control stimulation does not affect onset and offset of neuromuscular block...
23889295 - Increased mast cell numbers in a calcaneal tendon overuse model.
19968815 - A personalized approach to exercise promotion in adolescents with type 1 diabetes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  73     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-22     Completed Date:  1991-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  AIM; IM    
Department of Anesthesia, University of California, San Francisco 94143-0464.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Anesthetics / analysis,  pharmacokinetics*
Chromatography, Gas
Halothane / analysis,  pharmacokinetics*
Isoflurane / analogs & derivatives*,  analysis,  pharmacokinetics*
Pleura / metabolism*
Viscera / metabolism*
Reg. No./Substance:
0/Anesthetics; 151-67-7/Halothane; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A survey of 800 patients' knowledge, attitudes, and concerns regarding anesthesia.
Next Document:  Simultaneous comparison of intraarterial, oscillometric, and finapres monitoring during anesthesia.