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Visceral leishmaniasis (kala-azar) and pregnancy.
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MedLine Citation:
PMID:  15460194     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present review was to close the gap in the approach to pregnant women with visceral leishmaniasis (kala-azar) by providing up-to-date information to obstetricians about physiopathology, epidemiology, vertical transmission, drugs and treatment during pregnancy. BACKGROUND: Infection with Leishmania chagasi during pregnancy is rare and deserves special attention since little information is available regarding the occurrence of visceral leishmaniasis during gestational period and the real possibility of vertical transmission of this disease. Because specific areas in the world are endemic for the disease and considering the continuous growth of the population, cases of pregnant women with visceral leishmaniasis are becoming more frequent. Unfortunately, textbooks on infectious diseases do not include this specific group of patients, and studies in the literature on aspects related to pregnancy and visceral leishmaniasis are scarce. CONCLUSIONS: Vertical transmission of leishmaniasis is possible and the institution of treatment is imperative in cases of pregnant women with kala-azar. Amphotericin B is strongly recommended as the first choice drug due to its fewer maternal-fetal adverse effects.
Ernesto Antonio Figueiró-Filho; Geraldo Duarte; Patrícia El-Beitune; Silvana Maria Quintana; Tamara Lemos Maia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  12     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-04     Completed Date:  2004-10-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
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MeSH Terms
Amphotericin B / administration & dosage,  therapeutic use
Antimony / administration & dosage,  therapeutic use
Antiprotozoal Agents / administration & dosage,  therapeutic use
Infant, Newborn
Infectious Disease Transmission, Vertical
Leishmaniasis, Visceral / congenital,  prevention & control*,  transmission
Pregnancy Complications, Parasitic / prevention & control*
Reg. No./Substance:
0/Antiprotozoal Agents; 1397-89-3/Amphotericin B; 7440-36-0/Antimony

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Article Information
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Print publication date: Year: 2004
Volume: 12 Issue: 1
First Page: 31 Last Page: 40
ID: 1784584
PubMed Id: 15460194

Visceral leishmaniasis (kala-azar) and pregnancy.
Ernesto Antonio Figueir?-Filho Email:
Geraldo Duarte
Patr?cia El-Beitune
Silvana Maria Quintana
Tamara Lemos Maia
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, Brazil.

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