Document Detail

Visceral leishmaniasis in immunosuppressed Caucasian patient.
MedLine Citation:
PMID:  22605859     Owner:  NLM     Status:  MEDLINE    
A 64-year-old man was admitted with fever, weight loss, fatigue and night sweats. He was known to have rheumatoid arthritis and had been taking methotrexate for 1 year. He had worked in Saudi Arabia until 1994 and had been living in Spain for 6 months every year. Clinical examination showed an enlarged spleen. Routine investigations showed pancytopaenia. Serial blood cultures were negative. CT scan confirmed splenomegaly and was otherwise unremarkable. Bone marrow biopsy revealed Leishmania amastigote consistent with a diagnosis of visceral leishmaniasis. After discussing with the hospital for tropical diseases (HTD), he was started on liposomal amphotericin B. Following two infusions of amphotericin B, he started improving as his fever, night sweats and weakness had settled. He was then discharged and followed up in HTD clinic 4 weeks later where he was found to be consistently improving.
Muhammad Toqeer; Nadeem Rahman; Mark W Whitehead; Diana Lockwood
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-05-08
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-05-11    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Amphotericin B / therapeutic use*
Antiprotozoal Agents / therapeutic use*
Arthritis, Rheumatoid / complications
European Continental Ancestry Group
Leishmaniasis, Visceral / diagnosis*,  drug therapy*
Middle Aged
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antiprotozoal Agents; 0/liposomal amphotericin B; 7XU7A7DROE/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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