Document Detail

Visceral leishmaniasis during pregnancy treated with meglumine antimoniate.
MedLine Citation:
PMID:  7499009     Owner:  NLM     Status:  MEDLINE    
Data on the efficacy and safety of pentavalent antimony in the treatment of visceral leishmaniasis during pregnancy are scanty. A case of visceral leishmaniasis in a 39-year-old woman in the second trimester of pregnancy is reported here. The patient was hospitalized in poor condition with high fever and pancytopenia which had lasted for 6 weeks. A bone marrow aspirate revealed numerous amastigotes and serodiagnosis for Leishmania was positive at a high titer. The patient was successfully treated with meglumine antimoniate at a daily dose of 850 mg of antimony for 20 days. She delivered at term a healthy female baby who remains in good condition at 18 months of age. Thus a dose of 850 mg of antimony, which is lower than that presently recommended, seems to be effective and non toxic to the fetus when administered at the second trimester of pregnancy.
R Utili; A Rambaldi; M F Tripodi; A Andreana
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Infection     Volume:  23     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  182-3     Citation Subset:  IM    
Institute of Medical Therapy, Faculty of Medicine, 2nd University of Naples, Italy.
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MeSH Terms
Antiprotozoal Agents / therapeutic use*
Bone Marrow / parasitology
Infant, Newborn
Leishmania infantum / isolation & purification
Leishmaniasis, Visceral / drug therapy*
Meglumine / therapeutic use*
Organometallic Compounds / therapeutic use*
Pregnancy Complications, Parasitic / drug therapy*
Pregnancy Trimester, Second
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Organometallic Compounds; 133-51-7/meglumine antimoniate; 6284-40-8/Meglumine

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