Document Detail


Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B.
MedLine Citation:
PMID:  12458816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Visceral leishmaniasis is a worldwide, disseminated intracellular protozoal infection that usually manifests by fever, hepatosplenomegaly, anemia, thrombocytopenia, leukopenia and hypergammaglobulinemia. Although anemia is a usual finding, Coombs' positive hemolytic anemia has rarely been reported in association with this disease. Pentavalent antimonials have been the preferred treatment for this disease for decades, but increasing numbers of treatment failure with antimony are being reported. Liposomal amphotericin B is a new drug which is highly efficacious in the treatment of visceral leishmaniasis and produces minimal toxicity. Here we report an infant with visceral leishmaniasis associated with Coombs' positive hemolytic anemia who was successfully treated with liposomal amphotericin B.
Authors:
Embiya Dilber; Erol Erduran; Yasemin Işik
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  44     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2002 Oct-Dec
Date Detail:
Created Date:  2002-12-02     Completed Date:  2003-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  354-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / therapeutic use*
Anemia, Hemolytic / complications*
Antiprotozoal Agents / therapeutic use*
Coombs' Test
Female
Humans
Infant
Leishmaniasis, Visceral / complications,  drug therapy*
Liposomes
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Liposomes; 1397-89-3/Amphotericin B
Comments/Corrections
Comment In:
Turk J Pediatr. 2003 Jul-Sep;45(3):280   [PMID:  14696814 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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