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Visceral fat accumulation and metabolic syndrome in children: the impact of Trp64Arg polymorphism of the beta3-adrenergic receptor gene.
MedLine Citation:
PMID:  23282015     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To investigate the association between Trp64Arg polymorphism of the beta3-adrenergic receptor (ADRB3) gene and total fat mass, abdominal fat distribution, other metabolic derangements and metabolic syndrome (MS) in Japanese children. METHODS: Molecular screening of the ADRB3 gene polymorphism (Trp64Trp, Trp64Arg, and Arg64Arg) was carried out in 132 children aged 6-12 years: 73 were obese (45 boys) and 59 were not obese (27 boys). Visceral fat (VF) and subcutaneous fat (SF) area were measured using magnetic resonance imaging, blood pressure, lipid and glucose profiles. RESULTS: The frequencies of Arg carriers (Trp64Arg or Arg64Arg) were significantly higher in obese children with MS, compared to obese children without MS and non-obese children. In obese children, Arg carriers had significantly higher VF area, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol and triglyceride than Arg non-carriers (Trp64Trp). However, there were no differences in total fat mass and SF area between the two groups. In non-obese children, none of these parameters differed significantly between Arg carriers and non-carriers. CONCLUSION: Trp64Arg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS, a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in Japanese children. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Authors:
Kazuo Oguri; Toshiki Tachi; Toshio Matsuoka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Affiliation:
Faculty of Management, Shizuoka Sangyo University, 1572-1 Owara Iwata City, Shizuoka, 438-0043, Japan.
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