Document Detail

Visceral antinociception produced by bee venom stimulation of the Zhongwan acupuncture point in mice: role of alpha(2) adrenoceptors.
MedLine Citation:
PMID:  11457577     Owner:  NLM     Status:  MEDLINE    
The goal of the present study was to determine whether bee venom (BV) injection into the Zhongwan acupoint (CV12), compared to injection into a non-acupoint, produced antinociception in an acetic acid-induced visceral pain model. This was accomplished by injecting BV subcutaneously into the Zhongwan acupoint or into a non-acupoint 30 min before intraperitoneal injection of acetic acid in ICR mice. BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii. In contrast BV injection into the non-acupoint only produced antinociception at the highest dose of BV tested. Naloxone pretreatment did not alter the antinociceptive effect of BV acupoint injection on the abdominal stretch reflex. On the other hand, pretreatment with the alpha 2-adrenoceptor antagonist, yohimbine completely blocked the antinociceptive effect of BV acupoint injection. These results imply that BV acupoint stimulation can produce visceral antinociception that is associated with activation of alpha 2-adrenoceptors, but not with naloxone-sensitive opioid receptors.
Y B Kwon; M S Kang; H J Han; A J Beitz; J H Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  308     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, South Korea.
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MeSH Terms
Acetic Acid / pharmacology
Acupuncture Analgesia / methods*
Adrenergic alpha-Antagonists / pharmacology
Analgesics / pharmacology*
Bee Venoms / pharmacology*
Dose-Response Relationship, Drug
Injections, Intraperitoneal / adverse effects
Mice, Inbred ICR
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Neurons / cytology,  drug effects,  metabolism
Nociceptors / drug effects*,  physiology
Peritoneum / drug effects,  innervation,  physiopathology
Proto-Oncogene Proteins c-fos / drug effects,  metabolism
Receptors, Adrenergic, alpha-2 / drug effects*,  metabolism
Receptors, Opioid / drug effects,  metabolism
Solitary Nucleus / cytology,  drug effects,  metabolism
Spinal Cord / cytology,  drug effects*,  metabolism
Visceral Afferents / drug effects*,  physiology
Yohimbine / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Analgesics; 0/Bee Venoms; 0/Narcotic Antagonists; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Adrenergic, alpha-2; 0/Receptors, Opioid; 146-48-5/Yohimbine; 465-65-6/Naloxone; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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