Document Detail


Viruses in semen and male genital tissues--consequences for the reproductive system and therapeutic perspectives.
MedLine Citation:
PMID:  14965339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sexually transmissible diseases such as AIDS have renewed the attention paid to viruses capable of infecting the male genital tract. The presence of viruses at this level may not only lead to their transmission and spread via semen but may also impact on male fertility and/or represent a potential cause of genital organ cancers. This review summarizes the currently available data on the various viruses identified in the human semen and male reproductive tract, their distribution in tissues and fluids, their possible cell targets and the functional consequences of their infectivity on the reproductive and endocrine systems. The use of medically assisted reproduction as a therapeutic tool in serodiscordant couples, as well as treatment strategies that need to be developed in order to eradicate these viruses from the male genital tract, are discussed.
Authors:
N Dejucq-Rainsford; B Jégou
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  10     ISSN:  1381-6128     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2004  
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-09-09     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  557-75     Citation Subset:  IM    
Affiliation:
GERM-INSERM U435, Université de Rennes I, Campus de Beaulieu, 35 042 Rennes, France. nathalie.dejucq-rainsford@rennes.inserm.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / pharmacology,  therapeutic use*
Genital Diseases, Male / drug therapy,  virology*
Genitalia, Male / drug effects,  metabolism,  virology*
HIV-1 / drug effects,  physiology
Humans
Male
Reproduction / drug effects,  physiology
Semen / drug effects,  metabolism,  virology*
Simplexvirus / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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