Document Detail


Viruses in pharmaceutical research: pulmonary vascular disease.
MedLine Citation:
PMID:  21138278     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The management and understanding of pulmonary arterial hypertension (PAH) has undergone something of a revolution in the last 10 years, with new pharmacological agents entering routine clinical practice and significantly improving outcomes. Nevertheless many patients ultimately progress, and additional new treatment approaches are needed. There is now greater understanding of the molecular and genetic basis for the development of PAH, specifically in regard to the role of bone morphogenetic protein receptor 2 (BMPR2) signaling and related pathways. The challenge is to determine whether these new discoveries can be exploited for new therapies. In this article the role of viruses as tools for gene delivery for pulmonary vascular disease is discussed. Gene delivery of BMPR2 has now been shown to ameliorate the development and progression of PAH in animal models, thereby identifying this approach as a therapeutic target.
Authors:
Paul N Reynolds
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Publication Detail:
Type:  Journal Article     Date:  2010-12-22
Journal Detail:
Title:  Molecular pharmaceutics     Volume:  8     ISSN:  1543-8392     ISO Abbreviation:  Mol. Pharm.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197791     Medline TA:  Mol Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-64     Citation Subset:  IM    
Affiliation:
Department of Thoracic Medicine, Royal Adelaide Hospital, University of Adelaide and Hanson Institute, Australia.
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