Document Detail


Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging.
MedLine Citation:
PMID:  23334567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.
Authors:
Sharad Gupta; Muhammad R Chatni; Ayala L N Rao; Valentine I Vullev; Lihong V Wang; Bahman Anvari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-21
Journal Detail:
Title:  Nanoscale     Volume:  5     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-08-29     Revised Date:  2014-03-10    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  1772-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustics*
Adaptive Immunity / drug effects
Animals
Biomimetic Materials / chemistry*,  pharmacology
Cell Line, Tumor
Contrast Media / chemistry*,  pharmacology
Cytokines / metabolism
Humans
Indocyanine Green / chemistry*
Injections, Intravenous
Mice
Microscopy, Confocal
Nanostructures / chemistry*
Temperature
Viruses / chemistry*
Grant Support
ID/Acronym/Agency:
R01 CA134539/CA/NCI NIH HHS; R01 CA157277/CA/NCI NIH HHS; R01 EB000712/EB/NIBIB NIH HHS; R01 EB008085/EB/NIBIB NIH HHS; R01-CA134539/CA/NCI NIH HHS; R01-CA157277/CA/NCI NIH HHS; R01-CA159959/CA/NCI NIH HHS; R01-EB000712/EB/NIBIB NIH HHS; R01-EB008085/EB/NIBIB NIH HHS; U54-CA136398/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Cytokines; IX6J1063HV/Indocyanine Green
Comments/Corrections

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