Document Detail


Virus load and neuropathology in the FIV model.
MedLine Citation:
PMID:  8972419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The FIV (feline immunodeficiency virus) induces in cats brain changes presenting similarities with those observed in human immunodeficiency virus infection. This FIV model was used to study the relationship between viral load in brain, in lymphoid organs and central nervous system (CNS) changes during the early and late stages of infection. Early brain changes were analyzed in animals experimentally infected with two different FIV isolates and sacrificed at 7 and 15 days, 1, 2, 6, and 12 months post inoculation (p.i.). Late CNS abnormalities were analyzed in naturally FIV-infected cats referred to the Veterinary School of Nantes. For each animal, one cerebral hemisphere was fixed and examined using routine techniques. The characterization of FIV replicating cells by in situ hybridization was performed on the other half frozen hemisphere on sections performed in the anterior and the median regions of the brain. During the early stages of infection, moderate gliosis with glial nodules and sometimes white matter pallor and meningitis were associated with few infected cells scattered in the brain. Infection was an early event as infected cells could be detected in brain at 7 p.i. For each cat, these findings were found identical in the two analyzed areas. During the late stages, brain lesions and the number of virus replicating cells increased especially in animals with perivascular infiltrates. The multinucleated giant cells encephalitis was never observed and the number of FIV replicating cells scattered in the whole brain was always low. This discrepancy between the number of replicating cells and the brain lesions, corroborates the hypotheses suggesting that brain injuries may be mediated via diffusive factors and amplification processes through cytokine cascades and cell activations.
Authors:
D Boche; M Hurtrel; F Gray; M A Claessens-Maire; J P Ganière; L Montagnier; B Hurtrel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurovirology     Volume:  2     ISSN:  1355-0284     ISO Abbreviation:  J. Neurovirol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508123     Medline TA:  J Neurovirol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  377-87     Citation Subset:  IM; X    
Affiliation:
Unité d'Oncologie Virale, Institut Pasteur, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology,  virology
Cats
DNA, Viral / analysis
Disease Models, Animal
Feline Acquired Immunodeficiency Syndrome / physiopathology*,  virology*
Immunodeficiency Virus, Feline*
In Situ Hybridization
Lymph Nodes / pathology,  virology
Male
Nervous System Diseases / virology*
Viral Load*
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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