Document Detail

Virus-like particles-universal molecular toolboxes.
MedLine Citation:
PMID:  18083549     Owner:  NLM     Status:  MEDLINE    
Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-derived structural antigens. These stable and versatile subviral particles possess excellent adjuvant properties capable of inducing innate and cognate immune responses. Commercialised VLP-based vaccines have been successful in protecting humans from hepatitis B virus (HBV) and human papillomavirus (HPV) infection and are currently explored for their potential to combat other infectious diseases and cancer. Much insight into VLP-mediated immune stimulation and optimised VLP design has been gained from human immunodeficiency virus (HIV)-derived VLPs presenting promising components of current AIDS vaccine approaches. Owing to their unique features, VLPs and virosomes, the in vitro-reconstituted VLP counterparts, have recently gained ground in the field of nanobiotechnology as organic templates for the development of new biomaterials.
Christine Ludwig; Ralf Wagner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  18     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  537-45     Citation Subset:  IM    
Molecular Microbiology and Gene Therapy Unit, Institute of Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany.
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MeSH Terms
Antigens, Viral / immunology*
Drug Design*
Models, Biological
Viral Vaccines / immunology*
Reg. No./Substance:
0/Antigens, Viral; 0/Viral Vaccines

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