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Virus infection of the heart - unmet therapeutic needs.
MedLine Citation:
PMID:  22293868     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
For over 50 years viral infection has been recognized as an important trigger of acute myocarditis, inflammatory dilated cardiomyopathy (inflammatory DCM) and congestive heart failure. Nevertheless, viral heart disease remains challenging to diagnose and treat. Improved diagnostic methods for myocarditis have led to a better understanding of its pathophysiology. The recognition of virus-mediated damage, inflammation, and autoimmune dysregulation in these patients highlights the importance to differentiate between virus-positive and virus-negative inflammatory DCM. These insights have led to the development of novel treatment strategies, including intravenous immunoglobulin (IVIg) and interferon therapy for virus-positive patients. This article will emphasize on the pathogenesis of viral myocarditis, especially parvovirus B19-induced, its progression to inflammatory DCM and future treatment strategies.
Authors:
Mark Hazebroek; Robert Dennert; Stephane Heymans
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-01
Journal Detail:
Title:  Antiviral chemistry & chemotherapy     Volume:  -     ISSN:  2040-2066     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009212     Medline TA:  Antivir Chem Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, CARIM, University Hospital Maastricht, the Netherlands.
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