| Virus infections: lessons from pancreas histology. | |
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MedLine Citation:
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PMID: 20665131 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Type 1 diabetes mellitus is a chronic autoimmune disease resulting from the progressive immune-mediated destruction of pancreatic beta cells in genetically susceptible individuals, with the likely contribution of environmental factors, among which viruses have been extensively studied. The pathologic hallmark of the disease is insulitis-a process characterized by islet infiltration of immunocompetent cells that has been well characterized in animal models of islet autoimmunity, and to a lesser extent, in humans. Insulitis characterization has provided valuable information to gain insights into the disease pathogenesis. We review the recent literature on the viral contribution to beta-cell destruction and dysfunction in type 1 diabetes, with particular reference to the pathology of the pancreatic islet in humans and in animal models of the disease. |
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Authors:
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Francesco Dotta; Letizia Galleri; Guido Sebastiani; Francesco Vendrame |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current diabetes reports Volume: 10 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
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Languages: eng Pagination: 357-61 Citation Subset: IM |
Affiliation:
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Diabetes Unit, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, U.O. Diabetologia, University of Siena, Policlinico Le Scotte, Viale Bracci 18, Siena, Italy. francesco.dotta@alice.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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