| Virulence factor secretion and translocation by Bordetella species. | |
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MedLine Citation:
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PMID: 19186097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional secretion systems and secreted factors is provided. Particular attention is devoted to the Bsc type III secretion system (T3SS) and controversies surrounding it. Efforts to identify effector proteins, characterize in vitro and in vivo phenotypes, and the potential role of type III secretion during human infections are discussed. |
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Authors:
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Ruchi Shrivastava; Jeff F Miller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-01-29 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 12 ISSN: 1879-0364 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-23 Completed Date: 2009-03-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 88-93 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism* Bacterial Toxins / metabolism Bordetella / metabolism, pathogenicity* Host-Pathogen Interactions Humans Membrane Transport Proteins / metabolism* Protein Transport Virulence Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI061598/AI/NIAID NIH HHS; AI071204/AI/NIAID NIH HHS; R01 AI061598-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Bacterial Toxins; 0/Membrane Transport Proteins; 0/Virulence Factors |
| Comments/Corrections | |
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