| Virtual non-contrast in second-generation, dual-energy computed tomography: Reliability of attenuation values. | |
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MedLine Citation:
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PMID: 22236702 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the reliability of attenuation values in virtual non-contrast images (VNC) reconstructed from contrast-enhanced, dual-energy scans performed on a second-generation dual-energy CT scanner, compared to single-energy, non-contrast images (TNC). MATERIALS AND METHODS: Sixteen phantoms containing a mixture of contrast agent and water at different attenuations (0-1400HU) were investigated on a Definition Flash-CT scanner using a single-energy scan at 120kV and a DE-CT protocol (100kV/SN140kV). For clinical assessment, 86 patients who received a dual-phase CT, containing an unenhanced single-energy scan at 120kV and a contrast enhanced (110ml Iomeron 400mg/ml; 4ml/s) DE-CT (100kV/SN140kV) in an arterial (n=43) or a venous phase, were retrospectively analyzed. Mean attenuation was measured within regions of interest of the phantoms and in different tissue types of the patients within the corresponding VNC and TNC images. Paired t-tests and Pearson correlation were used for statistical analysis. RESULTS: For all phantoms, mean attenuation in VNC was 5.3±18.4HU, with respect to water. In 86 patients overall, 2637 regions were measured in TNC and VNC images, with a mean difference between TNC and VNC of -3.6±8.3HU. In 91.5% (n=2412) of all cases, absolute differences between TNC and VNC were under 15HU, and, in 75.3% (n=1986), differences were under 10HU. CONCLUSIONS: Second-generation dual-energy CT based VNC images provide attenuation values close to those of TNC. To avoid possible outliers multiple measurements are recommended especially for measurements in the spleen, the mesenteric fat, and the aorta. |
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Authors:
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Michael Toepker; Thomas Moritz; Bernhard Krauss; Michael Weber; Gordon Euller; Thomas Mang; Florian Wolf; Christian J Herold; Helmut Ringl |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Radiology, Medical University Vienna/Vienna General Hospital, Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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