| Virtual four-dimensional imaging of lung parenchyma by optical coherence tomography in mice. | |
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MedLine Citation:
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PMID: 20615018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this feasibility study, we present a method for virtual 4-D imaging of healthy and injured subpleural lung tissue in the ventilated mouse. We use triggered swept source optical coherence tomography (OCT) with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the inspiratory phase. The data acquisition is gated to the ventilation pressure to take single B-scans in each respiration cycle for different pressure levels. The acquired B-scans are combined off-line into one volume scan for each pressure level. The air fraction in healthy lungs and injured lungs is measured using 2-D OCT en-face images. Upon lung inspiration from 2 to 12 cm H(2)O ventilation pressure, the air fraction increases in healthy lungs by up to 11% and in injured lungs by 8%. This expansion correlates well with results of previous studies, reporting increased alveolar area with increased ventilation pressures. We demonstrate that OCT is a useful tool to investigate alveolar dynamics in spatial dimensions. |
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Authors:
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Sven Meissner; Arata Tabuchi; Michael Mertens; Wolfgang M Kuebler; Edmund Koch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 036016 Citation Subset: IM |
Affiliation:
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University of Technology Dresden, Clinical Sensoring and Monitoring, Medical Faculty, Fetscherstrasse 74, 01307 Dresden, Germany. sven.meissner@tu-dresden.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Image Processing, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Lung / anatomy & histology*, cytology, physiology Mice Pulmonary Alveoli / anatomy & histology, physiology Respiration Respiration, Artificial Tomography, Optical Coherence / methods* |
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