| A Virtual Culture of CD4+ T Lymphocytes. | |
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MedLine Citation:
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PMID: 23361399 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The CD4+ T cell lineages Th1, Th2, Th17, and Treg, are mammalian cell types that differentiate from the common precursor naive CD4+ T cell. While there is a wealth of experimental data regarding the molecular and cellular signals involved in the differentiation of CD4+ T cells in vitro, there is still no consensus regarding the structure of the network of interactions at the molecular and cellular levels controlling this differentiation process. In this work, a virtual culture of cells is constructed by interconnecting several instances of an updated version of the regulatory network controlling the differentiation process of CD4+ T cells in mice. The virtual culture is a multi-compartment model with an instance of a regulatory network inside each compartment, thus simulating a simplified version of a cell culture in a well-stirred reactor. The virtual culture is able to describe the stable molecular expression patterns described for fully differentiated CD4+ T cells in mice, as well as the differentiation process from a precursor to a given effector cell in response to specific molecular stimuli. |
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Authors:
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Luis Mendoza |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-30 |
Journal Detail:
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Title: Bulletin of mathematical biology Volume: - ISSN: 1522-9602 ISO Abbreviation: Bull. Math. Biol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401404 Medline TA: Bull Math Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, México, lmendoza@biomedicas.unam.mx. |
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