Document Detail


Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma.
MedLine Citation:
PMID:  22452816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current literature fully supports HPV (human papillomavirus)-associated OPSCC (oropharyngeal squamous cell carcinoma) as a unique clinical entity. It affects an unambiguous patient population with defined risk factors, has a genetic expression pattern more similar to cervical squamous cell carcinoma than non-HPV-associated HNSCC (head and neck squamous cell carcinoma), and may warrant divergent clinical management compared with HNSCC associated with traditional risk factors. However, a detailed understanding of the molecular mechanisms driving these differences and the ability to exploit this knowledge to improve clinical management of OPSCC has not yet come to fruition. The present review summarizes the aetiology of HPV-positive (HPV+) OPSCC and provides a detailed overview of HPV virology and molecular pathogenesis relevant to infection of oropharyngeal tissues. Methods of detection and differential gene expression analyses are also summarized. Future research into mechanisms that mediate tropism of HPV to oropharyngeal tissues, improved detection strategies and the pathophysiological significance of altered gene and microRNA expression profiles is warranted.
Authors:
Daniel L Miller; Michael D Puricelli; M Sharon Stack
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Biochemical journal     Volume:  443     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-28     Completed Date:  2012-05-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-53     Citation Subset:  IM    
Affiliation:
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Squamous Cell / genetics,  virology*
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Viral
Humans
Oropharyngeal Neoplasms / genetics,  virology*
Papillomavirus Infections / complications*,  genetics
Grant Support
ID/Acronym/Agency:
F31DE021926/DE/NIDCR NIH HHS; R01 CA085870/CA/NCI NIH HHS; R01CA085870/CA/NCI NIH HHS
Comments/Corrections

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