| Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 22452816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The current literature fully supports HPV (human papillomavirus)-associated OPSCC (oropharyngeal squamous cell carcinoma) as a unique clinical entity. It affects an unambiguous patient population with defined risk factors, has a genetic expression pattern more similar to cervical squamous cell carcinoma than non-HPV-associated HNSCC (head and neck squamous cell carcinoma), and may warrant divergent clinical management compared with HNSCC associated with traditional risk factors. However, a detailed understanding of the molecular mechanisms driving these differences and the ability to exploit this knowledge to improve clinical management of OPSCC has not yet come to fruition. The present review summarizes the aetiology of HPV-positive (HPV+) OPSCC and provides a detailed overview of HPV virology and molecular pathogenesis relevant to infection of oropharyngeal tissues. Methods of detection and differential gene expression analyses are also summarized. Future research into mechanisms that mediate tropism of HPV to oropharyngeal tissues, improved detection strategies and the pathophysiological significance of altered gene and microRNA expression profiles is warranted. |
| | |
Authors:
|
Daniel L Miller; Michael D Puricelli; M Sharon Stack |
Related Documents
:
|
19963256 - Intraprostatic abscess as a complication of salvage cryotherapy. 22493366 - A pilot study of letrozole for one year in women at enhanced risk of developing breast ... 22497626 - Clinicopathologic study of 1176 salivary gland tumors in a chinese population: experien... 21107076 - Painful breast lumps in nursing mothers. 9007826 - Biportal neuroendoscopic microsurgical approaches to the subarachnoid cisterns. a cadav... 1689206 - Management of benign prostatic hyperplasia. alternatives to standard therapy. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: The Biochemical journal Volume: 443 ISSN: 1470-8728 ISO Abbreviation: Biochem. J. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-03-28 Completed Date: 2012-05-14 Revised Date: 2013-04-17 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: England |
Other Details:
|
Languages: eng Pagination: 339-53 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma, Squamous Cell / genetics, virology* Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral Humans Oropharyngeal Neoplasms / genetics, virology* Papillomavirus Infections / complications*, genetics |
| Grant Support | |
ID/Acronym/Agency:
|
F31DE021926/DE/NIDCR NIH HHS; R01 CA085870/CA/NCI NIH HHS; R01CA085870/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Steroid-like signalling by interferons: making sense of specific gene activation by cytokines.
Next Document: Mousing around with caspases and IAPs.