Document Detail


Virology of hepatitis C virus.
MedLine Citation:
PMID:  8930439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatitis C virus (HCV) has been identified as the main causative agent of posttransfusion non-A, non-B hepatitis. Through recently developed diagnostic assays, routine serologic screening of blood donors has prevented most cases of posttransfusion hepatitis. The purpose of this paper is to comprehensively review current information regarding the virology of HCV. Recent findings on the genome organization, its relationship to other viruses, the replication of HCV ribonucleic acid, HCV translation, and HCV polyprotein expression and processing are discussed. Also reviewed are virus assembly and release, the variability of HCV and its classification into genotypes, the geographic distribution of HCV genotypes, and the biologic differences between HCV genotypes. The assays used in HCV genotyping are discussed in terms of reliability and consistency of results, and the molecular epidemiology of HCV infection is reviewed. These approaches to HCV epidemiology will prove valuable in documenting the spread of HCV in different risk groups, evaluating alternative (nonparenteral) routes of transmission, and in understanding more about the origins and evolution of HCV.
Authors:
P Simmonds
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical therapeutics     Volume:  18 Suppl B     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-36     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, University of Edinburgh Medical School, Scotland, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Genome, Viral
Hepacivirus / genetics,  immunology,  physiology*
Hepatitis C / epidemiology,  virology
Humans
Phylogeny
Protein Biosynthesis
RNA, Viral / genetics
Viral Proteins / genetics
Virus Replication
Chemical
Reg. No./Substance:
0/RNA, Viral; 0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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