Document Detail

Virology. HIV--breaking the rules for nuclear entry.
MedLine Citation:
PMID:  11691977     Owner:  NLM     Status:  MEDLINE    
How does human immunodeficiency virus (HIV) gain access to the carefully guarded nucleus of the host cell? In a Perspective, Segura-Totten and Wilson elaborate on new findings (de Noronha et al.) showing that the HIV protein Vpr is crucial for causing transient herniations in the host cell nuclear envelope. These ruptures are sufficient to enable the preintegration complexes of invading virions to enter the nucleus and to integrate with host cell DNA.
M Segura-Totten; K L Wilson
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  294     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1016-7     Citation Subset:  IM    
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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MeSH Terms
Cell Nucleus / metabolism*,  virology*
Chromatin / metabolism
DNA-Binding Proteins / metabolism
G2 Phase
Gene Products, vpr / genetics,  metabolism*
HIV / physiology*
Hela Cells
Membrane Proteins / metabolism
Nuclear Envelope / metabolism*,  ultrastructure
Nuclear Proteins / metabolism
Thymopoietins / metabolism
Virus Integration*
vpr Gene Products, Human Immunodeficiency Virus
Reg. No./Substance:
0/BANF1 protein, human; 0/Chromatin; 0/DNA-Binding Proteins; 0/Gene Products, vpr; 0/Lamins; 0/Membrane Proteins; 0/Nuclear Proteins; 0/Thymopoietins; 0/emerin; 0/lamina-associated polypeptide 2; 0/vpr Gene Products, Human Immunodeficiency Virus
Comment On:
Science. 2001 Nov 2;294(5544):1105-8   [PMID:  11691994 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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