Document Detail

Virological and serological studies of neurological complications of acute hemorrhagic conjunctivitis in Thailand.
MedLine Citation:
PMID:  192809     Owner:  NLM     Status:  MEDLINE    
An extensive outbreak of acute hemorrhagic conjunctivitis (AHC) occurred from September to December 1974 in Thailand. At least 29 patients with polio-like motor paralysis that complicated AHC were hospitalized in Bangkok. Paired or triplicate samples of serum from 16 patients were tested for neutralizing antibody to enterovirus type 70 (EV70). A significant rise in titer of antibody was found for two patients, and the other 14 had neutralizing antibody titers ranging from 1:8 to 1:512 without an increasf larger than or equal to 1:16, a level which is considered to be diagnostically significant. Neutralizing antibody to EV70 was detected in 19S fractions of nine sera examined, but neutralizing antibody to three types of poliovirus was confined to 7S fractions. EV70 was isolated from one of seven stool specimens collected on day 37 after the onset of AHC and none of 10 samples of cerebrospinal fluid. These results and additional clinical and epidemiologic findings gave further support to the hypothesis that EV70 infection can cause polio-like motor paralysis as a complication of AHC.
R Kono; K Miyamura; E Tajiri; A Sasagawa; P Phuapradit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  135     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  706-13     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Viral / analysis*
Cerebrospinal Fluid
Conjunctivitis / complications,  microbiology*
Disease Outbreaks
Enterovirus / immunology*,  isolation & purification
Feces / microbiology
Immunoglobulin M / analysis
Neurologic Manifestations
Neutralization Tests
Paralysis / etiology
Poliovirus / immunology,  isolation & purification
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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