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Virologic and Immunologic Outcomes of the Second-Line Regimens of Antiretroviral Therapy Among HIV-Infected Patients in Thailand.
MedLine Citation:
PMID:  21368017     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Goal of the second-line therapy among HIV-1-infected patients is to re-establish virological suppression, although treatment options in resource-limited settings are limited. An observational cohort of patients with first-line antiretroviral therapy (ART) failure was conducted in a university hospital in Thailand. Of 95 patients, mean age 39 years, 65% were male. Median CD4 and HIV-1 RNA at second-line ART initiation were 158 cells/mm(3) and 4.1 copies/mL, respectively. Boosted protease inhibitor plus 2 nucleoside reverse transcriptase inhibitors (NRTIs), indicated by genotype results, was commonly used as second-line regimen. At 6, 12, 24, and 36 months of second-line ART, 67%, 62%, 84%, and 90% of patients achieved HIV-1 RNA <50 copies/mL; median CD4 were 258, 366, 444, and 522 cells/mm( 3), respectively. Good adherence, high baseline CD4, and early Centers for Centers for Disease Control and Prevention (CDC) staging were associated with virologic success (P < .05). Second-line ART based on the results of genotype testing yields the good virologic and immunologic outcomes in a resource-limited setting, and scaling-up of second-line ART is indicated.
Authors:
May Myat Win; Wirach Maek-A-Nantawat; Benjaluck Phonrat; Sasisopin Kiertiburanakul; Somnuek Sungkanuparph
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)     Volume:  10     ISSN:  1545-1097     ISO Abbreviation:  J Int Assoc Physicians AIDS Care (Chic)     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185740     Medline TA:  J Int Assoc Physicians AIDS Care (Chic)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-63     Citation Subset:  IM    
Affiliation:
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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