Document Detail


Virally encoded chemokine binding proteins.
MedLine Citation:
PMID:  16178725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Virus-encoded immune evasion mechanisms provide information on viral pathogenesis and offer a unique opportunity to identify new strategies of immune modulation. Secreted proteins that bind a broad range of chemokines have been identified in recent years in poxviruses and herpesviruses. We discuss the properties of these viral chemokine inhibitors and their potential as new therapeutics to treat human inflammatory diseases.
Authors:
Louise M C Webb; Antonio Alcami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  5     ISSN:  1389-5575     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-23     Completed Date:  2006-03-28     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  833-48     Citation Subset:  IM    
Affiliation:
Department of Medicine and Division of Virology, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ Eden 28049 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / chemistry,  pharmacology,  therapeutic use
Chemokines / antagonists & inhibitors,  metabolism*
Humans
Protein Binding
Viral Proteins / antagonists & inhibitors,  chemistry,  metabolism*
Virus Diseases / metabolism,  pathology
Viruses / metabolism
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Chemokines; 0/Viral Proteins

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