Document Detail


Viral modulators of cell death provide new links to old pathways.
MedLine Citation:
PMID:  14644194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By observing how viruses facilitate their parasitic relationships with host cells, we gain insights into key regulatory pathways of the cell. Not only are mitochondria key players in the regulation of programmed cell death, but many viral regulators of cell death also alter mitochondrial functions either directly or indirectly. Although cytomegalovirus vMIA and Epstein-Barr virus BHRF1 seem to have opposite effects on mitochondrial morphology, they both inhibit cell death. Drosophila Reaper, a regulator of developmental cell death, acts on IAP (inhibitor of apoptosis) proteins to activate caspases, but can regulate mitochondrial permeability in vitro. Despite its pivotal role in Drosophila, homologues of Reaper in other species were not previously known. Recently, amino acid sequence similarity was recognized between Drosophila Reaper and a protein known to be important for the replication and virulence of mosquito-borne bunyaviruses that cause human encephalitis. Thus, viral mechanisms for regulating apoptosis are diverse and not fully elucidated but promise to provide new insights.
Authors:
Pablo M Irusta; Ying-bei Chen; J Marie Hardwick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  15     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  700-5     Citation Subset:  IM    
Affiliation:
Department of Molecular Microbiology, Johns Hopkins Schools of Medicine and Public Health, 615 North Wolfe St, Baltimore, Maryland 21205, USA. pirusta@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Biological Transport
Cell Death*
Drosophila
Drosophila Proteins / metabolism*
Immediate-Early Proteins / physiology
Mitochondria / metabolism,  pathology*
Models, Biological
Orthobunyavirus / metabolism
Viral Proteins / metabolism,  physiology
Xenopus
Grant Support
ID/Acronym/Agency:
R01 CA73581/CA/NCI NIH HHS; R01 NS34175/NS/NINDS NIH HHS; R01 NS37402/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/BHRF1 protein, Human herpesvirus 4; 0/Drosophila Proteins; 0/Immediate-Early Proteins; 0/UL37 protein, Human herpesvirus 5; 0/Viral Proteins; 0/reaper protein, Drosophila

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