| Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. | |
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MedLine Citation:
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PMID: 20561901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic exposure to cocaine increases the activity of extracellular signal-regulated kinase (ERK1/2) in the ventral tegmental area (VTA), a neural substrate for drugs of abuse. However, the functional significance of changes in ERK1/2 activity in this brain region is unknown. Using herpes simplex virus-mediated gene transfer to regulate ERK2 activity within the VTA in male rats, we show that overexpressing ERK2 increases preference for environments previously paired with low doses of cocaine and enhances cocaine-induced locomotion, whereas blocking ERK2 activity blocks cocaine-induced place conditioning and locomotor activity. These results demonstrate that ERK2-signaling within the VTA is a key modulator of functional responses to cocaine. |
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Authors:
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Sergio D Iñiguez; Brandon L Warren; Rachael L Neve; Scott J Russo; Eric J Nestler; Carlos A Bolaños-Guzmán |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Behavioural brain research Volume: 214 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-16 Revised Date: 2011-12-26 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 460-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychology and Program in Neuroscience, The Florida State University, 1107 West Call Street, Tallahassee, FL 32306, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Choice Behavior / drug effects, physiology* Cocaine / pharmacology* Conditioning (Psychology) / drug effects, physiology* Gene Transfer Techniques Genetic Vectors Male Mitogen-Activated Protein Kinase 1 / genetics, metabolism* Motor Activity / drug effects* Rats Rats, Sprague-Dawley Rats, Transgenic Simplexvirus / genetics* Ventral Tegmental Area / metabolism*, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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F31DA027300/DA/NIDA NIH HHS; R01 DA014133-11/DA/NIDA NIH HHS; R01 DA014133-12/DA/NIDA NIH HHS; R01 DA026854-01A1/DA/NIDA NIH HHS; R01 DA026854-02/DA/NIDA NIH HHS; R21 DA022351-02/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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