Document Detail


Viral infections and molecular mimicry in type 1 diabetes.
MedLine Citation:
PMID:  23051179     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulin-producing beta cells, leading to their progressive destruction. The condition constitutes a significant and worldwide problem to human health, particularly because of its rapid, but thus far unexplained, increase in incidence. Environmental factors such as viral infections are thought to account for this trend. While there is no lack of reports associating viral infections toT1D, it has proven difficult to establish which immunological processes link viral infections to disease onset or progression. One of the commonly discussed pathways is molecular mimicry, a mechanism that encompasses cross-reactive immunity against epitopes shared between viruses and beta cells. In this review, we will take a closer look at mechanistic evidence for a potential role of viruses in T1D, with a special focus on molecular mimicry.
Authors:
Ken T Coppieters; Anna Wiberg; Matthias G von Herrath
Related Documents :
23252179 - Zero central-line infections in a 550-bedded district general hospital.
22989109 - Mycobacterium ulcerans infection: evolution in clinical management.
22981919 - Mdm2 regulates a novel form of incomplete neoplastic transformation of theileria parva ...
21493649 - Lessons from animal studies for the treatment of invasive human infections due to uncom...
23582969 - Mannheimia haemolytica a1-induced fibrinosuppurative meningoencephalitis in a naturally...
24167679 - Clozapine treatment of patients with refractory schizophrenia, concurrent dengue infect...
208489 - Latent herpes simplex virus in ganglia of mice after primary infection and reinoculatio...
8531649 - The use and limitations of ultrasonography in the diagnosis of liver morbidity attribut...
20182399 - Local production of inflammatory mediators during childhood parainfluenza virus infection.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  -     ISSN:  1600-0463     ISO Abbreviation:  APMIS     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors APMIS © 2012 APMIS.
Affiliation:
Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patient satisfaction after gut-directed hypnotherapy in irritable bowel syndrome.
Next Document:  Incorporating latitudinal and central-marginal trends in assessing genetic variation across species ...