Document Detail


Viral-encoded enzymes that target host chromatin functions.
MedLine Citation:
PMID:  19716451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ever since their existence, there has been an everlasting arms race between viruses and their host cells. Host cells have developed numerous strategies to silence viral gene expression whereas viruses always find their ways to overcome these obstacles. Recent studies show that viruses have also evolved to take full advantage of existing cellular chromatin components to activate or repress its own genes when needed. While in most cases viruses encode certain proteins to recruit or inhibit cellular factors through physical interactions, growing examples show that viral-encoded enzymes affect host chromatin structure through post-translationally modifying histones or other cellular proteins important for chromatin function. The most well-studied example is vSET encoded by paramecium bursaria chlorella virus 1. vSET specifically methylates histone H3 at lysine 27, causing genome-wide silencing of Polycomb target genes upon infection, thus mimicking the function of Polycomb repressive complex 2 (PRC2) in eukaryotes. Other examples include BGLF4 from Epstein-Barr virus that affects both condensin and topoisomerase II activity and Us3 from Herpes Simplex virus 1 that inhibits HDAC1 function through phosphorylation.
Authors:
Hua Wei; Ming-Ming Zhou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-08-27
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1799     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-05-11     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Copyright Information:
2009 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatin / metabolism*
DNA Methylation
Gene Expression Regulation
Gene Silencing*
Histones / metabolism
Humans
Transcription, Genetic
Viral Proteins / metabolism*
Virion / enzymology*
Grant Support
ID/Acronym/Agency:
R01 GM073207/GM/NIGMS NIH HHS; R01 GM073207-04/GM/NIGMS NIH HHS; RC1 DA028776/DA/NIDA NIH HHS; RC1 DA028776-01/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/Viral Proteins
Comments/Corrections

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