| Viral-associated trichodysplasia of immunosuppression: report of a pediatric patient with response to oral valganciclovir. | |
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MedLine Citation:
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PMID: 20713819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Viral-associated trichodysplasia of immunosuppression is an increasingly recognized entity characterized by follicular-based papules, primarily in the central part of the face, that produce variable degrees of alopecia and dysmorphic features. It has been primarily described in transplant recipients but has recently been recognized in patients receiving chemotherapy for leukemia and lymphoma. It is associated with distinctive histologic features such as dilated anagen hair follicles, absent hair papillae, and abrupt cornification of the inner root sheath. OBSERVATIONS: A 5-year-old boy presented with spiny follicular papules that caused thickening of the skin of the face 1 year after cardiac transplantation. He had been exposed to several immunosuppressive agents, including mycophenolate mofetil, tacrolimus, intravenous immunoglobulin, rituximab, cylcophosphamide, and prednisone. Despite the failure of multiple topical treatments, our patient's eruption improved with systemic valganciclovir therapy. CONCLUSIONS: We describe the youngest patient (to our knowledge) with viral-associated trichodysplasia of immunosuppression and discuss the characteristic clinicopathologic features. Our report supports the theory that immunosuppression is the predisposing factor to a folliculotropic papovavirus that alters follicular maturation. |
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Authors:
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Taylor Benoit; Rocky Bacelieri; Dean S Morrell; John Metcalf |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 146 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 871-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, 135 Rutledge Ave., Charleston, SC 29425, USA. benoitm@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Age Factors Antiviral Agents / administration & dosage, therapeutic use* Child, Preschool Facial Dermatoses / drug therapy*, pathology, virology Ganciclovir / administration & dosage, analogs & derivatives*, therapeutic use Heart Transplantation / methods Humans Immunocompromised Host Immunosuppressive Agents / adverse effects, therapeutic use Male |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Immunosuppressive Agents; 0/valganciclovir; 82410-32-0/Ganciclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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