Document Detail


Viral Infectivity Factor: A Novel Therapeutic Strategy to Block HIV-1 Replication.
MedLine Citation:
PMID:  23621690     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The HIV-1 viral infectivity factor (Vif), one of the six accessory proteins, is essential for viral replication and pathogenesis. Its main function is to form Vif-Cullin5-ElonginBC complex and then is able to ubiquitinate and degrade the human anti-viral factor APOBEC3G, which markedly enhances the virus infectivity. Delete Vif leads to the loss of the infectivity of HIV-1; therefore, Vif is a potentially new attractive target for therapeutic intervention in AIDS. This review describes the structure, function and especially inhibitors of HIV-1 Vif.
Authors:
Guliang Yang; Xujie Xiong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  13     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1047-55     Citation Subset:  IM    
Affiliation:
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, College of Chemistry and Life Science, Huanggang Normal University, No. 146, Xingang 2 Road, Huanggang 438000, Hubei, P.R. China. guliang_yang@163.com.
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