| Viral Determinants of HIV-1 Macrophage Tropism. | |
| | |
MedLine Citation:
|
PMID: 22163344 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Macrophages are important target cells for HIV-1 infection that play significant roles in the maintenance of viral reservoirs and other aspects of pathogenesis. Understanding the determinants of HIV-1 tropism for macrophages will inform HIV-1 control and eradication strategies. Tropism for macrophages is both qualitative (infection or not) and quantitative (replication capacity). For example many R5 HIV-1 isolates cannot infect macrophages, but for those that can the macrophage replication capacity can vary by up to 1000-fold. Some X4 viruses are also capable of replication in macrophages, indicating that cellular tropism is partially independent of co-receptor preference. Preliminary data obtained with a small number of transmitted/founder viruses indicate inefficient macrophage infection, whereas isolates from later in disease are more frequently tropic for macrophages. Thus tropism may evolve over time, and more macrophage tropic viruses may be implicated in the pathogenesis of advanced HIV-1 infection. Compartmentalization of macrophage-tropic brain-derived envelope glycoproteins (Envs), and non-macrophage tropic non-neural tissue-derived Envs points to adaptation of HIV-1 quasi-species in distinct tissue microenvironments. Mutations within and adjacent to the Env-CD4 binding site have been identified that determine macrophage tropism at the entry level, but post-entry molecular determinants of macrophage replication capacity involving HIV-1 accessory proteins need further definition. |
| | |
Authors:
|
Christopher J A Duncan; Quentin J Sattentau |
Related Documents
:
|
15268624 - Novel therapy for crohn's disease targeting il-6 signalling. 16266194 - Biologic therapy for inflammatory bowel disease. 16048554 - Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulato... 19735074 - Targeted therapy to the il-2r using diphtheria toxin and caspase-3 fusion proteins modu... 20360404 - Release of il-12 by dendritic cells activated by tlr ligation is dependent on myd88 sig... 21044044 - Kojic acid, a secondary metabolite from aspergillus sp., acts as an inducer of macropha... |
Publication Detail:
|
Type: Journal Article Date: 2011-11-15 |
Journal Detail:
|
Title: Viruses Volume: 3 ISSN: 1999-4915 ISO Abbreviation: Viruses Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101509722 Medline TA: Viruses Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 2255-79 Citation Subset: IM |
Affiliation:
|
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK; E-Mail: quentin.sattentau@path.ox.ac.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hepatitis C virus assembly imaging.
Next Document: Hepatitis C virus evasion mechanisms from neutralizing antibodies.