| Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R. BR) root extract. | |
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MedLine Citation:
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PMID: 9604294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present investigation explored the possible venom neutralizing effect of a pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from the methanolic root extract of Hemidesmus indicus R.Rr. 2-OH-4-MeO benzoic acid possessed potent anti-inflammatory, antipyretic and antioxidant properties. The compound effectively neutralized inflammation induced by Vipera russelli venom in male albino mice and reduced cotton pellet-induced granuloma in rats. The compound produced a significant fall in body temperature in yeast-induced pyrexia in rats but did not change the normothermic body temperature. The compound effectively neutralized viper venom-induced changes in serum phosphatase and transaminase activity in male albino rats. It also neutralized free radical formation as estimated by TBAPS and superoxide dismutase activities. The antisnake venom activity of the pure compound is partly mediated through the above physiological process. |
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Authors:
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M I Alam; A Gomes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 36 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-08-10 Completed Date: 1998-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 207-15 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Calcutta, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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antagonists & inhibitors,
blood Alkaline Phosphatase / antagonists & inhibitors, blood Animals Anti-Inflammatory Agents / pharmacology Benzoates / chemistry, isolation & purification* Body Temperature / drug effects Free Radicals Guinea Pigs Inflammation / chemically induced* Lipid Peroxidation / drug effects Male Medicine, Ayurvedic Mice Plant Extracts / chemistry* Plant Roots / chemistry* Plants, Medicinal / chemistry* Rats Russell's Viper Viper Venoms / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/2-hydroxy-4-methoxy benzoic acid; 0/Anti-Inflammatory Agents; 0/Benzoates; 0/Free Radicals; 0/Plant Extracts; 0/Viper Venoms; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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