Document Detail

ε-Viniferin is more effective than its monomer resveratrol in improving the functions of vascular endothelial cells and the heart.
MedLine Citation:
PMID:  22738966     Owner:  NLM     Status:  MEDLINE    
The present study compared the effects of resveratrol and its dimer ε-viniferin on vascular endothelial cells (VECs) functions, and on the blood pressure and cardiac mass of spontaneously hypertensive rats (SHRs). Treatment of VECs with these compounds enhanced cell proliferation via nitric oxide generation and protected the cells from oxidative stress by suppressing increases in intracellular oxygen species. ε-Viniferin was more potent than resveratrol in most of these effects. ε-Viniferin, but not resveratrol inhibited angiotensin-converting enzyme activity in vitro. Three weeks of ε-viniferin treatment (5 mg/kg) reduced the systolic blood pressure and improved the whole cardiac mass and left ventricle mass indexes in SHRs. In contrast, resveratrol administration (2.5 mg/kg) failed to lower the blood pressure and significantly improve these mass indexes. These data suggest that ε-viniferin as well as resveratrol may be involved in protecting the functions of VECs and the heart.
Nahla Zghonda; Shigeki Yoshida; Shoji Ezaki; Yoshie Otake; Chie Murakami; Ahmed Mliki; Abdelwahed Ghorbel; Hitoshi Miyazaki
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Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-28     Completed Date:  2012-10-26     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  954-60     Citation Subset:  IM    
Graduate School of Life and Environmental Sciences, Tsukuba University, Ibaraki, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antioxidants / pharmacology*
Benzofurans / pharmacology*
Blood Pressure / drug effects
Cell Proliferation / drug effects
Cell Survival / drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Endothelial Cells / drug effects*,  metabolism,  pathology
Myocardium / pathology*
Nitric Oxide / biosynthesis
Organ Size / drug effects
Oxidative Stress / drug effects
Peptidyl-Dipeptidase A / metabolism
Rats, Inbred SHR
Rats, Wistar
Reactive Oxygen Species / antagonists & inhibitors
Stilbenes / pharmacology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antioxidants; 0/Benzofurans; 0/Reactive Oxygen Species; 0/Stilbenes; 10102-43-9/Nitric Oxide; 62218-08-0/epsilon-viniferin; EC A; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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