| ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart. | |
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MedLine Citation:
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PMID: 22738966 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study compared the effects of resveratrol and its dimer ε-viniferin on vascular endothelial cells (VECs) functions, and on the blood pressure and cardiac mass of spontaneously hypertensive rats (SHRs). Treatment of VECs with these compounds enhanced cell proliferation via nitric oxide generation and protected the cells from oxidative stress by suppressing increases in intracellular oxygen species. ε-Viniferin was more potent than resveratrol in most of these effects. ε-Viniferin, but not resveratrol inhibited angiotensin-converting enzyme activity in vitro. Three weeks of ε-viniferin treatment (5 mg/kg) reduced the systolic blood pressure and improved the whole cardiac mass and left ventricle mass indexes in SHRs. In contrast, resveratrol administration (2.5 mg/kg) failed to lower the blood pressure and significantly improve these mass indexes. These data suggest that ε-viniferin as well as resveratrol may be involved in protecting the functions of VECs and the heart. |
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Authors:
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Nahla Zghonda; Shigeki Yoshida; Shoji Ezaki; Yoshie Otake; Chie Murakami; Ahmed Mliki; Abdelwahed Ghorbel; Hitoshi Miyazaki |
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Publication Detail:
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Type: Journal Article Date: 2012-05-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 76 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 954-60 Citation Subset: IM |
Affiliation:
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Graduate School of Life and Environmental Sciences, Tsukuba University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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