Document Detail

Vincristine induced cranial neuropathy.
MedLine Citation:
PMID:  22799120     Owner:  NLM     Status:  MEDLINE    
Neuropathy is a well known side effect of vincristine, however cranial nerve toxicities are reported less frequently which can involve any cranial nerve in mostly bilateral pattern. As many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction, the potential for misdiagnosis is high. Here, along with review of literature we describe three cases on vincristine who developed cranial neuropathy while on treatment.
Gaurav Dixit; Atul Dhingra; Diksha Kaushal
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  60     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-07-17     Completed Date:  2012-08-07     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  56-8     Citation Subset:  IM    
Department of Medicine, Pt. B.D. Sharma PGIMS, Rohtak 124001.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects*
Cholinesterase Inhibitors / therapeutic use
Cranial Nerve Diseases / chemically induced*,  drug therapy
Neurotoxicity Syndromes / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications,  drug therapy*
Pyridostigmine Bromide / therapeutic use
Pyridoxine / therapeutic use
Treatment Outcome
Vincristine / adverse effects*
Vitamin B Complex / therapeutic use
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Cholinesterase Inhibitors; 101-26-8/Pyridostigmine Bromide; 12001-76-2/Vitamin B Complex; 57-22-7/Vincristine; 65-23-6/Pyridoxine

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