| Vincristine-induced peripheral neuropathy in a neonate with congenital acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 20216233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 46-day-old boy with a fulminant vincristine-induced peripheral neuropathy after treatment for congenital acute lymphoblastic leukemia. Flaccid paralysis developed at the end of the first phase of induction, requiring intubation and ventilation for 51 days. Treatment was initiated with levocarnitine, N-acetylcysteine, and pyridoxine and progressive reversal of the neuropathy occurred over the next 4 months. Potential differences in pathogenesis and presentation of vincristine neurotoxicity and Guillian-Barre syndrome in the neonate are discussed. |
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Authors:
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Steven K Baker; David M Lipson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-05-06 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: e114-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Physical Medicine & Neurology, Neuromuscular Disease Clinic, McMaster University Medical Centre, McMaster University, Hamilton, Ontario, Canada. bakersk@mcmaster.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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therapeutic use Antineoplastic Agents, Phytogenic / adverse effects* Carnitine / therapeutic use Drug Therapy, Combination Free Radical Scavengers / therapeutic use Humans Infant Male Peripheral Nervous System Diseases / chemically induced*, drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma / congenital*, drug therapy* Pyridoxine / therapeutic use Vincristine / adverse effects* Vitamin B Complex / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Free Radical Scavengers; 12001-76-2/Vitamin B Complex; 541-15-1/Carnitine; 57-22-7/Vincristine; 616-91-1/Acetylcysteine; 65-23-6/Pyridoxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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