Document Detail

Vincristine and intestinal pseudo-obstruction in children: report of 5 cases, literature review, and suggested management.
MedLine Citation:
PMID:  20418785     Owner:  NLM     Status:  MEDLINE    
Intestinal pseudo-obstruction is a rare complication resulting from a variety of disorders. Symptoms include abdominal pain, nausea, vomiting, diarrhea, constipation, and malnutrition. Vincristine-related pseudo-obstruction has been reported in the literature, but its description in children and recommendations for management are lacking. A review of the literature revealed 21 reported pediatric cases of vincristine-related pseudo-obstruction. Most have, however, been attributed to a drug interaction with itraconazole, accidental vincristine overdose, or liver failure. Potential genetic causes are rarely addressed. We present here 5 cases of pseudo-obstruction related to vincristine without any identifiable predisposing factors, and a suggested algorithm for management.
Manuel Diezi; Andreas Nydegger; Ermindo R Di Paolo; Henri Kuchler; Maja Beck-Popovic
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  32     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-05-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e126-30     Citation Subset:  IM    
Pediatric Hemato-Oncology Unit, Department of Pediatrics, Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects*
Child, Preschool
Hodgkin Disease / drug therapy*
Intestinal Pseudo-Obstruction / chemically induced*,  therapy
Kidney Neoplasms / drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Survival Rate
Treatment Outcome
Vincristine / adverse effects*
Wilms Tumor / drug therapy*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 57-22-7/Vincristine

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