| Vincristine and intestinal pseudo-obstruction in children: report of 5 cases, literature review, and suggested management. | |
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MedLine Citation:
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PMID: 20418785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUMMARY: Intestinal pseudo-obstruction is a rare complication resulting from a variety of disorders. Symptoms include abdominal pain, nausea, vomiting, diarrhea, constipation, and malnutrition. Vincristine-related pseudo-obstruction has been reported in the literature, but its description in children and recommendations for management are lacking. A review of the literature revealed 21 reported pediatric cases of vincristine-related pseudo-obstruction. Most have, however, been attributed to a drug interaction with itraconazole, accidental vincristine overdose, or liver failure. Potential genetic causes are rarely addressed. We present here 5 cases of pseudo-obstruction related to vincristine without any identifiable predisposing factors, and a suggested algorithm for management. |
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Authors:
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Manuel Diezi; Andreas Nydegger; Ermindo R Di Paolo; Henri Kuchler; Maja Beck-Popovic |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-05-27 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: e126-30 Citation Subset: IM |
Affiliation:
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Pediatric Hemato-Oncology Unit, Department of Pediatrics, Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland. manuel.diezi@chuv.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Algorithms Antineoplastic Agents, Phytogenic / adverse effects* Child Child, Preschool Female Hodgkin Disease / drug therapy* Humans Intestinal Pseudo-Obstruction / chemically induced*, therapy Kidney Neoplasms / drug therapy Male Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Survival Rate Treatment Outcome Vincristine / adverse effects* Wilms Tumor / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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