Document Detail


Vinblastine plus cisplatin in advanced non-small cell lung cancer: lack of advantage for vinblastine infusion schedule.
MedLine Citation:
PMID:  3004727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have evaluated 31 patients with advanced non-small cell lung cancer treated by short-term 5-day vinblastine infusion combined with bolus cisplatin. Nine of 31 patients (29%) had partial and complete responses. Although five of nine (55%) of the responders were alive at greater than or equal to 1 year, three of the 31 patients experienced drug-related mortality. Our experience, as well as a review of previously reported trials in the literature, suggests that the infusion schedule of vinblastine offers no advantage over the bolus schedule.
Authors:
M Huberman; J Lokich; R Greene; S Paul; D Phillips; H Sonneborn; T Zipoli
Related Documents :
18505067 - Induction chemotherapy followed by concurrent chemoradiotherapy in advanced head and ne...
2306797 - Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protec...
21243027 - High-dose chemotherapy and asct in elderly patients with hodgkin's lymphoma.
21174157 - Combined thermal-surgical ablation of locally advanced abdominopelvic malignancies.
10773147 - Importance of the control of lung recurrence soon after surgery of pulmonary metastases.
7023667 - Surgery for common epithelial tumors of the ovary.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer treatment reports     Volume:  70     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Small Cell / drug therapy
Carcinoma, Squamous Cell / drug therapy
Cisplatin / administration & dosage
Female
Humans
Lung Neoplasms / drug therapy*
Male
Middle Aged
Vinblastine / administration & dosage
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phase II trial of 5-FU, vincristine, and mitomycin (FOMi) in metastatic bronchioloalveolar cell lung...
Next Document:  Synthesis of methyl 6-(ammonium 2-acetamido-2-deoxy-alpha-D-glucopyranosyl phosphate)-alpha-D-mannop...