Document Detail

Vinblastine plus cisplatin in advanced non-small cell lung cancer: lack of advantage for vinblastine infusion schedule.
MedLine Citation:
PMID:  3004727     Owner:  NLM     Status:  MEDLINE    
We have evaluated 31 patients with advanced non-small cell lung cancer treated by short-term 5-day vinblastine infusion combined with bolus cisplatin. Nine of 31 patients (29%) had partial and complete responses. Although five of nine (55%) of the responders were alive at greater than or equal to 1 year, three of the 31 patients experienced drug-related mortality. Our experience, as well as a review of previously reported trials in the literature, suggests that the infusion schedule of vinblastine offers no advantage over the bolus schedule.
M Huberman; J Lokich; R Greene; S Paul; D Phillips; H Sonneborn; T Zipoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer treatment reports     Volume:  70     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-9     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / drug therapy
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Small Cell / drug therapy
Carcinoma, Squamous Cell / drug therapy
Cisplatin / administration & dosage
Lung Neoplasms / drug therapy*
Middle Aged
Vinblastine / administration & dosage
Reg. No./Substance:
15663-27-1/Cisplatin; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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