| Villotrophoblastic pulmonary nodule with implantation site intermediate trophoblasts after induced abortion. | |
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MedLine Citation:
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PMID: 17581416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of villotrophoblastic pulmonary nodule with a hitherto unrecognized implantation site intermediate trophoblasts (ISITs) in an asymptomatic 19-year-old woman, who had an induced abortion 1 month before the discovery of a pulmonary nodule. This 8-mm-sized nodule was incidentally identified on chest computed tomography during routine postoperative follow-up for osteosarcoma, for which she was treated with surgery and chemotherapy 3 years previously. The nodule was located in the subpleural lung parenchyma and was composed histologically of a few chorionic villi and trophoblasts surrounded by fibrinoid materials, with individually scattered intermediate trophoblasts at the periphery of the nodule. The intermediate trophoblasts were strongly immunopositive for cytokeratin, human placental lactogen, and Mel-CAM (CD146), but immunonegative for human chorionic gonadotropin and p63, characteristic features of ISITs. Our case indicates that villotrophoblastic pulmonary emboli have the potential to implant after migration from their original sites through the invasive property of ISITs. |
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Authors:
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Dong Eun Song; Se J Jang; Kyu-Rae Kim |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Volume: 26 ISSN: 0277-1691 ISO Abbreviation: Int. J. Gynecol. Pathol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-21 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214845 Medline TA: Int J Gynecol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 305-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Adult Chorionic Villi / pathology Female Humans Immunohistochemistry Lung Neoplasms / pathology*, surgery Trophoblastic Neoplasms / pathology*, surgery Trophoblasts / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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